期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 4, 页码 1441-1450出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2420-12.2013
关键词
-
资金
- United States Public Health Service Grant [DA15408]
Stress, which involves a heightened arousal and excitability, triggers important adaptive responses to maintain homeostasis and prepare a response. In the current studies, we administered a psychological stressor of 2 h acute restraint on rats, and found that 24 h after the cessation of the restraint session, there was a significant decrease in ventral tegmental area dopaminergic (DA) neuron population activity and a significant attenuation in amphetamine-induced locomotor activity. Systemic or intra-basolateral nuclei of the amygdala administration of the beta-noradrenergic receptor antagonist, propranolol, reversed the decrease, suggesting that the delayed attenuation ofDAneuron firing following a stressor depends on a noradrenaline-mediated mechanism. This alteration in DA activity may adaptively prepare the individual to avoid the stressor, or in the extreme, may be a factor that contributes to pathological changes in behavior or physiological responses.
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