期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 16, 页码 6800-6808出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1044-12.2013
关键词
-
资金
- Burroughs Wellcome Fund Career Award at the Scientific Interface
- Pew Charitable Trusts Scholarship in the Biomedical Sciences
- National Institutes of Health [EY023020-01]
- Research to Prevent Blindness Career Development Award
- Edward N. & Della L. Thome Memorial Foundation
- National Institute of Health [EY02576, EY015128, EY014800, EY18608-05]
- National Science Foundation [0941717]
- Air Force Office of Scientific Research [FA9550-10-1-0503]
- Department of Defense [W81XWH-12-10575]
- Stanford University Bio-X Grant
CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina after injury or disease was thought to be limited to restructuring resulting in abnormal retinal anatomy and function. Here we report that neurons in the mammalian retina change their connectivity and restore normal retinal anatomy and function after injury. Patches of photoreceptors in the rabbit retina were destroyed by selective laser photocoagulation, leaving retinal inner neurons (bipolar, amacrine, horizontal, ganglion cells) intact. Photoreceptors located outside of the damaged zone migrated to make new functional connections with deafferented bipolar cells located inside the lesion. The new connections restored ON and OFF responses in deafferented ganglion cells. This finding extends the previously perceived limits of restorative plasticity in the adult retina and allows for new approaches to retinal laser therapy free of current detrimental side effects such as scotomata and scarring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据