期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 5, 页码 1858-1863出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4405-12.2013
关键词
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资金
- Swiss National Science Foundation [320030-124897, IZK0Z3_139473/1]
- Centre d'Imagerie BioMedicale of the Universite de Lausanne
- Universite de Geneve
- Hopitaux Universitaires de Geneve
- Lausanne University Hospital
- Ecole Polytechnique Federale de Lausanne
- Leenaards Foundation
- Louis-Jeantet Foundation
- Swiss National Science Foundation (SNF) [IZK0Z3_139473, 320030_124897] Funding Source: Swiss National Science Foundation (SNF)
Cocktail parties, busy streets, and other noisy environments pose a difficult challenge to the auditory system: how to focus attention on selected sounds while ignoring others? Neurons of primary auditory cortex, many of which are sharply tuned to sound frequency, could help solve this problem by filtering selected sound information based on frequency-content. To investigate whether this occurs, we used high-resolution fMRI at 7 tesla to map the fine-scale frequency-tuning (1.5 mm isotropic resolution) of primary auditory areas A1 and R in six human participants. Then, in a selective attention experiment, participants heard low (250 Hz)- and high (4000 Hz)-frequency streams of tones presented at the same time (dual-stream) and were instructed to focus attention onto one stream versus the other, switching back and forth every 30 s. Attention to low-frequency tones enhanced neural responses within low-frequency-tuned voxels relative to high, and when attention switched the pattern quickly reversed. Thus, like a radio, human primary auditory cortex is able to tune into attended frequency channels and can switch channels on demand.
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