期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 14, 页码 6081-6092出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0035-13.2013
关键词
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资金
- National Institutes of Health [R01-NS059957]
- March of Dimes [6-FY10-289]
- Duke Fellowship in Postdoctoral Training Program in Fundamental and Translational Neuroscience
- Janos Bolyai Research Fellowship from the Hungarian Academy of Sciences
- Hungarian Scientific Research Fund (OTKA) [K83830]
- NIDA [R01DA027807]
- NIMH [U19 MH082441]
- North Carolina Biotechnology Center
- NINDS [R01NS035527, R01NS068410]
- HHMI
Despite evidence for a strong genetic contribution to several major psychiatric disorders, individual candidate genes account for only a small fraction of these disorders, leading to the suggestion that multigenetic pathways may be involved. Several known genetic risk factors for psychiatric disease are related to the regulation of actin polymerization, which plays a key role in synaptic plasticity. To gain insight into and test the possible pathogenetic role of this pathway, we designed a conditional knock-out of the Arp2/3 complex, a conserved final output for actin signaling pathways that orchestrates de novo actin polymerization. Here we report that postnatal loss of the Arp2/3 subunit ArpC3 in forebrain excitatory neurons leads to an asymmetric structural plasticity of dendritic spines, followed by a progressive loss of spine synapses. This progression of synaptic deficits corresponds with an evolution of distinct cognitive, psychomotor, and social disturbances as the mice age. Together, these results point to the dysfunction of actin signaling, specifically that which converges to regulate Arp2/3, as an important cellular pathway that may contribute to the etiology of complex psychiatric disorders.
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