期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 43, 页码 17089-17094出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0522-13.2013
关键词
-
资金
- Fondation pour la Recherche Medicale postdoctoral fellowship
- INSERM ATIP-AVENIR grant
- Agence Nationale pour la Recherche (ANR) [ANR-2010-BLAN-1128-01]
- ANR
The sense of touch allows an organism to detect and respond to physical environmental stimuli. Mechanosensitive proteins play a crucial role in this process by converting the mechanical cue into a biological response. Recently, the Piezo family of stretch-activated ion channels has been identified as genuine mechanosensitive proteins. We set out to determine whether any of these genes are involved in touch response during zebrafish development. In situ hybridization indicates that piezo2b is specifically expressed in a subset of neurons (Rohon-Beard cells) responsible for detecting light touch. Using morpholino-mediated knockdown, we specifically targeted piezo2b and determined that it is involved in mediating touch-evoked response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据