期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 22, 页码 7493-7498出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0719-12.2012
关键词
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资金
- Swiss National Science Foundation [31003A_135735/1]
- Swiss National Science Foundation (SNF) [31003A_135735] Funding Source: Swiss National Science Foundation (SNF)
Peripheral nerve hyperexcitability (PNH) is one of the distal peripheral neuropathy phenotypes often present in patients affected by type 2 diabetes mellitus (T2DM). Through in vivo and ex vivo electrophysiological recordings in db/db mice, a model of T2DM, we observed that, in addition to reduced nerve conduction velocity, db/db mice also develop PNH. By using pharmacological inhibitors, we demonstrated that the PNH is mediated by the decreased activity of K(v)1-channels. In agreement with these data, we observed that the diabetic condition led to a reduced presence of the K(v)1.2-subunits in juxtaparanodal regions of peripheral nerves in db/db mice and in nerve biopsies from T2DM patients. Together, these observations indicate that the T2DM condition leads to potassium channel-mediated PNH, thus identifying them as a potential drug target to treat some of the DPN related symptoms.
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