期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 42, 页码 14532-14537出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3509-12.2012
关键词
-
资金
- NIH [NS054791, GM087369, NS047399, NS014624]
beta-alanine, a popular supplement for muscle building, induces itch and tingling after consumption, but the underlying molecular and neural mechanisms are obscure. Here we show that, in mice, beta-alanine elicited itch-associated behavior that requires MrgprD, a G-protein-coupled receptor expressed by a subpopulation of primary sensory neurons. These neurons exclusively innervate the skin, respond to beta-alanine, heat, and mechanical noxious stimuli but do not respond to histamine. In humans, intradermally injected beta-alanine induced itch but neither wheal nor flare, suggesting that the itch was not mediated by histamine. Thus, the primary sensory neurons responsive to beta-alanine are likely part of a histamine-independent itch neural circuit and a target for treating clinical itch that is unrelieved by anti-histamines.
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