期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 10, 页码 3376-3387出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4248-11.2012
关键词
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资金
- National Centres of Competence in Research-Neural Plasticity and Repair, Swiss National Science Foundation [ETH-01 08-1]
- Zurich Neuroscience Center
- Novartis Foundation
- Theodore Ott Foundation
- U.S. National Institute of Neurological Disorders and Stroke
- Lookout Fund
- Christopher and Dana Reeve Foundation
- Picower Foundation
- James S. McDonnell Foundation
- German Academic Exchange Service
- Damon Runyon Cancer Research Foundation [DRG-1859-05]
- Janggen-Pohn Foundation
Neural stem cells (NSCs) generate neurons throughout life in the hippocampal dentate gyrus (DG). How gene expression signatures differ among NSCs and immature neurons remains largely unknown. We isolated NSCs and their progeny in the adult DG using transgenic mice expressing a GFP reporter under the control of the Sox2 promoter (labeling NSCs) and transgenic mice expressing a DsRed reporter under the control of the doublecortin (DCX) promoter (labeling immature neurons). Transcriptome analyses revealed distinct gene expression profiles between NSCs and immature neurons. Among the genes that were expressed at significantly higher levels in DG NSCs than in immature neurons was the growth factor insulin-like growth factor 2 (IGF2). We show that IGF2 selectively controls proliferation of DG NSCs in vitro and in vivo through AKT-dependent signaling. Thus, by gene expression profiling of NSCs and their progeny, we have identified IGF2 as a novel regulator of adult neurogenesis.
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