期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 32, 页码 10833-10840出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5628-11.2012
关键词
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资金
- University of Texas Medical Branch start-up funds
- Whitehall Foundation
- National Institutes of Health [U01-MH-083507, R24-NS-045491]
Studies with animal models have suggested that reaction of glia, including microglia and astrocytes, critically contributes to the development and maintenance of chronic pain. However, the involvement of glial reaction in human chronic pain is unclear. We performed analyses to compare the glial reaction profiles in the spinal dorsal horn (SDH) from three cohorts of sex- and age-matched human postmortem tissues: (1) HIV-negative patients, (2) HIV-positive patients without chronic pain, and (3) HIV patients with chronic pain. Our results indicate that the expression levels of CD11b and Iba1, commonly used for labeling microglial cells, did not differ in the three patient groups. However, GFAP and S100 beta, often used for labeling astrocytes, were specifically upregulated in the SDH of the pain-positive HIV patients but not in the pain-negative HIV patients. In addition, proinflammatory cytokines, TNF alpha and IL-1 beta, were specifically increased in the SDH of pain-positive HIV patients. Furthermore, proteins in the MAPK signaling pathway, including pERK, pCREB and c-Fos, were also upregulated in the SDH of pain-positive HIV patients. Our findings suggest that reaction of astrocytes in the SDH may play a role during the maintenance phase of HIV-associated chronic pain.
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