期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 10, 页码 3393-3397出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4339-11.2012
关键词
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资金
- National Institute of Mental Health [R01 MH062122]
- Charles F. Scott Endowed Fellowship
Mammals suffering damage to the hippocampus display a dramatic loss of explicit, recently formed memories (retrograde amnesia). In contrast, deficits in the ability to form new memories following hippocampal damage (anterograde amnesia) can be overcome with sufficient training. By combining contextual fear conditioning with lesions of the dorsal hippocampus in rats, we discovered that while animals can form long-term contextual fear memories in the absence of the hippocampus, these memories decay with time, lacking the permanence that is a hallmark characteristic of normal fear memories. These findings indicate that while it is initially possible to acquire explicit memories when the hippocampus is compromised, these memories cannot transfer from a recent to remote state. This suggests that memories formed outside the hippocampus may nevertheless require the hippocampus to undergo systems consolidation, which has important clinical implications for the treatment of memory disorders.
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