期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 3, 页码 966-971出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4007-11.2012
关键词
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资金
- Academy of Finland
- Sigrid Juselius Foundation
- Signe and Ane Gyllenberg Foundation
- Paivikki and Sakari Sohlberg Foundation
- Helsinki Biomedical Graduate School
In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.
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