期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 25, 页码 8686-8695出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1533-12.2012
关键词
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资金
- National Institutes of Health-National Institute of Dental and Craniofacial Health
- National Center for Research Resources-NIH
- National Institute of Neurological Disorders and Stroke
Here we used an array-based differential screen to uncover the expression of the neuropeptide neuromedin B (NMB) in the trigeminal ganglia of mice. Double-labeling experiments reveal NMB is expressed in a subset of sensory neurons that colabel with calcitonin gene-related peptide and TRPV1 suggestive of a role for NMB in nociception. Indeed, administration of NMB antagonist greatly attenuates edema and nerve sensitization following stimulation of peripheral nerves with mustard oil, demonstrating that NMB contributes to neurogenic inflammation. Moreover, direct injection of NMB causes local swelling and nociceptive sensitization. Interestingly, we also find that the receptor for NMB is expressed in interneurons in the superficial layers of the dorsal horn. We used NMB-saporin to specifically eliminate NMBR-expressing neurons and determined they are required in responses to noxious heat, but not for reaction to mechanical and pruritic stimuli. Thus, NMB may be a neurotransmitter that is selectively involved in the perception of thermal stimuli.
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