期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 42, 页码 15048-15052出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3164-11.2011
关键词
-
资金
- Canadian Institutes of Health Research (CIHR) [MOP77583, 97821]
- Frederick Banting Canada Graduate Scholarship Doctoral Award
- Charles Best Canada Graduate Scholarship Doctoral Award
Adaptive decision making involves selecting the most valuable option, typically by taking an action. Such choices require value comparisons, but there is debate about whether these comparisons occur at the level of stimuli (goods-based) value, action-based value, or both. One view is that value processes occur in series, with stimulus value informing action value. However, lesion work in nonhuman primates suggests that these two kinds of choice are dissociable. Here, we examined action-value and stimulus-value learning in humans with focal frontal lobe damage. Orbitofrontal damage disrupted the ability to sustain the correct choice of stimulus, but not of action, after positive feedback, while damage centered on dorsal anterior cingulate cortex led to the opposite deficit. These findings argue that there are distinct, domain-specific mechanisms by which outcome value is applied to guide subsequent decisions, depending on whether the choice is between stimuli or between actions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据