期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 21, 页码 7811-7816出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1504-11.2011
关键词
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资金
- State of California for medical research on alcohol and substance abuse through the University of California, San Francisco
- Wheeler Center for the Neurobiology of Addiction
The midbrain ventral tegmental area (VTA) projection to the nucleus accumbens (NAc) is implicated in motivation and reinforcement. A significant number of NAc medium spiny neurons (MSNs) project back to the VTA, although the nature of this projection is essentially unknown. For example, do NAc MSNs directly target accumbens-projecting dopamine neurons and do they act via the GABA(A) or GABA(B) receptor? To address these issues, we expressed the light-sensitive channel rhodopsin-2 in the rat NAc and made electrophysiological recordings from VTA neurons ex vivo. We found that the NAc directly targets non-dopaminergic VTA neurons, including some that project back to the NAc. These MSN GABAergic terminals are opioid sensitive and act via GABA(A) receptors.
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