期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 24, 页码 8760-8769出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0564-11.2011
关键词
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资金
- NIH [R21 EY018320, R01 EY11310, R01 EY013528]
- E. Matilda Ziegler Foundation for the Blind
- NSF [10S-0818983]
- Human Frontier Science Program Organization
- National Postdoctoral Award Program for Advancing Women in Science
- Edmond and Lily Safra (ELSC) Fellowship for Postdoctoral Training in Brain Science
- NIH American Recovery & Reinvestment Act [EY019498]
On-Off direction-selective retinal ganglion cells (DSGCs) encode the axis of visual motion. They respond strongly to an object moving in a preferred direction and weakly to an object moving in the opposite, null, direction. Historically, On-Off DSGCs were classified into four subtypes according to their directional preference (anterior, posterior, superior, or inferior). Here, we compare two genetically identified populations of On-Off DSGCs: dopamine receptor 4 (DRD4)-DSGCs and thyrotropin-releasing hormone receptor (TRHR)-DSGCs. We find that although both populations are tuned for posterior motion, they can be distinguished by a variety of physiological and anatomical criteria. First, the directional tuning of TRHR-DSGCs is broader than that of DRD4-DSGCs. Second, whereas both populations project similarly to the dorsal lateral geniculate nucleus, they project differently to the ventral lateral geniculate nucleus and the superior colliculus. Moreover, TRHR-DSGCs, but not DRD4-DSGCs, also project to the zona incerta, a thalamic area not previously known to receive direction-tuned visual information. Our findings reveal unexpected diversity among mouse On-Off DSGC subtypes that uniquely process and convey image motion to the brain.
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