期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 39, 页码 13860-13869出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1340-11.2011
关键词
-
资金
- NIH [DA10900, DA017318]
The mesolimbic dopamine projection from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) is critical in mediating reward-related behaviors, but the precise role of dopamine in this process remains unknown. We completed a series of studies to examine whether coincident changes occur in NAc cell firing and rapid dopamine release during goal-directed behaviors for sucrose and if so, to determine whether the two are causally linked. We show that distinct populations of NAc neurons differentially encode sucrose-directed behaviors, and using a combined electrophysiology/electrochemistry technique, further show that it is at those locations that rapid dopamine signaling is observed. To determine causality, NAc cell firing was recorded during selective pharmacological inactivation of dopamine burst firing using the NMDA receptor antagonist, AP-5. We show that phasic dopamine selectively modulates excitatory but not inhibitory responses of NAc neurons during sucrose-seeking behavior. Thus, rapid dopamine signaling does not exert global actions in the NAc but selectively modulates discrete NAc microcircuits that ultimately influence goal-directed actions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据