期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 49, 页码 17917-17922出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1903-11.2011
关键词
-
资金
- National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services
- NIDA Residual Research Services [N01DA-5-9909]
Intravenous cocaine intake in laboratory animals is characterized by periods of apparent drug satiety between regularly spaced earned injections. The reinforcing properties of cocaine are linked primarily to dopaminergic neurotransmission in the shell and not the core of nucleus accumbens. To determine whether the satiating effects of cocaine are similarly mediated, we perfused dopamine receptor agonists into the core or the shell during intravenous cocaine self-administrations by rats. Neither D1-type (SKF38393) nor D2-type (quinpirole) agonist was effective when given alone. However, a combination of the two agonists perfused into the core but not the shell significantly increased the time between cocaine self-injections, decreasing the amount of earned intake. Together with previous findings, the current data suggest that the satiating and reinforcing effects of cocaine are mediated by different ventral striatal output neurons.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据