期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 8, 页码 2769-2780出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4991-10.2011
关键词
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资金
- Sandler Postdoctoral Research Fellowship
- National Eye Institute [EY01869]
- March of Dimes
- Research to Prevent Blindness
- National Institutes of Health [NS038297]
- National Institute of Neurological Disorders and Stroke [NS16033]
Inhibitory interneurons play a critical role in coordinating the activity of neural circuits. To explore the mechanisms that direct the organization of inhibitory circuits, we analyzed the involvement of tropomyosin-related kinase B (TrkB) in the assembly and maintenance of GABAergic inhibitory synapses between Golgi and granule cells in the mouse cerebellar cortex. We show that TrkB acts directly within each cell-type to regulate synaptic differentiation. TrkB is required not only for assembly, but also maintenance of these synapses and acts, primarily, by regulating the localization of synaptic constituents. Postsynaptically, TrkB controls the localization of a scaffolding protein, gephyrin, but acts at a step subsequent to the localization of a cell adhesion molecule, Neuroligin-2. Importantly, TrkB is required for the localization of an Ig superfamily cell adhesion molecule, Contactin-1, in Golgi and granule cells and the absence of Contactin-1 also results in deficits in inhibitory synaptic development. Thus, our findings demonstrate that TrkB controls the assembly and maintenance of GABAergic synapses and suggest that TrkB functions, in part, through promoting synaptic adhesion.
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