期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 23, 页码 8001-8011出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4636-09.2010
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- National Institutes of Health National Center for Research Resources
- Grants-in-Aid for Scientific Research [21370002, 20115002] Funding Source: KAKEN
Insulin signaling plays a prominent role in regulation of dauer formation and longevity in Caenorhabditis elegans. Here, we show that insulin signaling also is required in benzaldehyde-starvation associative plasticity, in which worms pre-exposed to the odor attractant benzaldehyde in the absence of food subsequently demonstrate a conditioned aversion response toward the odorant. Animals with mutations in insulin-related 1 (ins-1), abnormal dauer formation 2 (daf-2), and aging alteration 1 (age-1), which encode the homolog of human insulin, insulin/IGF-1 receptor, and PIP3 kinase, respectively, demonstrated significant deficits in benzaldehyde-starvation associative plasticity. Using a conditional allele, we show that the behavioral roles of DAF-2 signaling in associative plasticity can be dissociated, with DAF-2 signaling playing a more significant role in the memory retrieval than in memory acquisition. We propose DAF-2 signaling acts as a learning-specific starvation signal in the memory acquisition phase of benzaldehyde-starvation associative plasticity but functions to switch benzaldehyde-sensing amphid wing C neurons into an avoidance signaling mode during memory retrieval.
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