期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 14, 页码 4914-4921出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5166-09.2010
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada
- Alberta Scholarship Programs
- Soroptimist International of Toronto
- Rotman Research Institute, Baycrest
- Canadian Institutes of Health Research [MOP14036, MOP13026]
- James S. McDonnell Foundation
- Canada Research Chairs program
- Ontario Research Fund
- Canadian Foundation for Innovation
Functional magnetic resonance imaging (fMRI) research often attributes blood oxygen level-dependent (BOLD) signal variance to measurement-related confounds. However, what is typically considered noise variance in data may be a vital feature of brain function. We examined fMRI signal variability during fixation baseline periods, and then compared SD- and mean-based spatial patterns and their relations with chronological age (20-85 years). We found that not only was the SD-based pattern robust, it differed greatly, both spatially and statistically, from the mean-based pattern. Notably, the unique age-predictive power of the SD-based pattern was more than five times that of the mean-based pattern. This reliable SD-based pattern of activity highlights an important signal within what is often considered measurement-related noise. We suggest that examination of BOLD signal variability may reveal a host of novel brain-related effects not previously considered in neuroimaging research.
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