期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 9, 页码 3347-3357出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5267-09.2010
关键词
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资金
- National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases [HD09020, DK42271, EY02660]
Maturation of the mammalian nervous system requires adequate provision of thyroid hormone and mechanisms that enhance tissue responses to the hormone. Here, we report that the development of cones, the photoreceptors for daylight and color vision, requires protection from thyroid hormone by type 3 deiodinase, a thyroid hormone-inactivating enzyme. Type 3 deiodinase, encoded by Dio3, is expressed in the immature mouse retina. In Dio3(-/-) mice, similar to 80% of cones are lost through neonatal cell death. Cones that express opsin photopigments for response to both short (S) and medium-long (M) wavelength light are lost. Rod photoreceptors, which mediate dim light vision, remain essentially intact. Excessive thyroid hormone in wild-type pups also eliminates cones. Cone loss is mediated by cone-specific thyroid hormone receptor beta 2 (TR beta 2) as deletion of TR beta 2 rescues cones in Dio3(-/-) mice. However, rescued cones respond to short but not longer wavelength light because TR beta 2 under moderate hormonal stimulation normally induces M opsin and controls the patterning of M and S opsins over the retina. The results suggest that type 3 deiodinase limits hormonal exposure of the cone to levels that safeguard both cone survival and the patterning of opsins that is required for cone function.
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