期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 30, 页码 10067-10075出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1776-10.2010
关键词
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资金
- National Institutes of Health-National Institute on Deafness and Other Communication Disorders [DC00210, DC006291, DC006972, DC007600, DC003159]
- Yale Medical Scientist Training Program [GM0720]
- Yale University School of Medicine Office of Student Research
- [F30 DC010324]
As odorant receptors (ORs) are thought to be critical determinants of olfactory sensory neuron (OSN) axon targeting and organization, we examined the spatiotemporal onset of mice ORs expression from the differentiation of OSNs in the olfactory placode to an aging olfactory epithelium. ORs were first detected in the placode at embryonic day 9 (E9), at the onset of OSN differentiation but before axon extension. By E13, 22 of 23 ORs were expressed. Onset of individual OR expression was diverse; levels and patterns of expression were unique for each OR. Regional distribution of ORs within zones of the olfactory epithelium appeared stable across development; adult-like patterns were observed by E13. Finally, analysis of OR expression and chromosomal location suggests that ORs are not stochastically expressed; they show evidence of coordinated expression. Collectively, these studies demonstrate that ORs are not equally represented in the olfactome across an animal's lifespan.
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