期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 37, 页码 12414-12423出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3135-10.2010
关键词
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资金
- Centre National de la Recherche Scientifique
- Action Thematique et Incitative sur Programme
- Agence Nationale pour la Recherche [ANR-Neuro-2006]
- Fondation pour le Recherche Medicale
- Association Francaise contre les Myopathies
Nociceptors in peripheral ganglia display a remarkable functional heterogeneity. They can be divided into the following two major classes: peptidergic and nonpeptidergic neurons. Although RUNX1 has been shown to play a pivotal role in the specification of nonpeptidergic neurons, the mechanisms driving peptidergic differentiation remain elusive. Here, we show that hepatocyte growth factor (HGF)-Met signaling acts synergistically with nerve growth factor-tyrosine kinase receptor A to promote peptidergic identity in a subset of prospective nociceptors. We provide in vivo evidence that a population of peptidergic neurons, derived from the RUNX1 lineage, require Met activity for the proper extinction of Runx1 and optimal activation of CGRP(calcitonin gene-related peptide). Moreover, we show that RUNX1 in turn represses Met expression in nonpeptidergic neurons, revealing a bidirectional cross talk between Met and RUNX1. Together, our novel findings support a model in which peptidergic versus nonpeptidergic specification depends on a balance between HGF-Met signaling and Runx1 extinction/maintenance.
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