期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 15, 页码 5404-5414出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4893-09.2010
关键词
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资金
- Research to Prevent Blindness
- March of Dimes Basil
- That Man May See
- National Institutes of Health-National Eye Institute [T32 EY07120]
- Achievement Rewards for College Scientists Foundation Scholarship
Neuronal pentraxins (NPs) are hypothesized to play important roles in the recruitment of AMPA receptors (AMPARs) to immature synapses, yet a physiological role for NPs at nascent synapses in vivo has remained elusive. Here we report that the loss of NP1 and NP2 (NP1/2) leads to a dramatic and specific reduction in AMPAR-mediated transmission at developing visual system synapses. In thalamic slices taken from early postnatal mice (
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