期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 7, 页码 2694-2699出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0567-09.2010
关键词
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资金
- National Science Foundation [SBE 0354378]
- National Institute of Mental Health [P50 MH062196]
- National Institutes of Health [RO1 MH061975, MH068404, MH055678]
- Deutsche Forschungsgemeinschaft
Although the hippocampus plays a crucial role in encoding and retrieval of contextually mediated episodic memories, considerable controversy surrounds the role of the hippocampus in short-term or working memory. To examine both hippocampal and neocortical contributions to working memory function, we recorded electrocorticographic activity from widespread cortical and subcortical sites as 20 neurosurgical patients performed working memory tasks. These recordings revealed significant increases in 48-90 Hz gamma oscillatory power with memory load for two classes of stimuli: letters and faces. Sites exhibiting gamma increases with memory load appeared primarily in the hippocampus and medial temporal lobe. These findings implicate gamma oscillatory activity in the maintenance of both letters and faces in working memory and provide the first direct evidence for modulation of hippocampal gamma oscillations as humans perform a working memory task.
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