期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 42, 页码 14029-14035出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3366-10.2010
关键词
-
资金
- State of California for medical research on alcohol and substance abuse through the University of California, San Francisco
- National Institute on Drug Abuse [DA015232, DA019958]
GABA transmission in the ventral tegmental area (VTA) is critical for fine tuning the activity of dopamine neurons in response to opioids. However, the precise mechanism by which GABA input shapes opioid reward is poorly understood. We observed a reduction of conditioned place preference for low doses of the opioid [D-Ala2, N-MePhe4, Gly5-ol]-enkephalin(DAMGO) and a switch in the functional effects of mu-opioid receptor modulation of GABA postsynaptic currents in the mouse VTA 1 d after chronic morphine treatment. Specifically, whereas in naive mice DAMGO inhibits GABA postsynaptic currents, GABAergic currents are potentiated by DAMGO after chronic morphine treatment. Importantly, pretreatment with the cAMP signaling inhibitor (R)-adenosine, cyclic 3', 5'-(hydrogenphosphorothioate) triethylammonium both restored DAMGO reward and reversed the DAMGO-mediated potentiation, thereby reestablishing the inhibitory effects of opioids on GABA currents. Thus, a paradoxical bidirectionality in mu-receptor-mediated control of GABA transmission following chronic morphine treatment is a critical mechanism that determines the expression of opioid reward in the VTA.
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