期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 26, 页码 8965-8973出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4030-09.2010
关键词
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资金
- Faculty of Medicine
- Georg-August-Universitat Gottingen
- Deutsche Forschungsgemeinschaft Research Center Molecular Physiology of the Brain
- Cluster of Excellence [171]
Cannabinoids modulate the activity of many neuronal cells, among them sensory neurons in the olfactory epithelium. Here we show that the endocannabinoid 2-arachidonoyl-glycerol (2-AG) is synthesized in both olfactory receptor neurons and glia-like sustentacular cells in larval Xenopus laevis. Its production in the latter depends on the hunger state of the animal. The essential effect of 2-AG in olfactory receptor neurons is the control of odorant detection thresholds via cannabinoid CB1 receptor activation. Hunger renders olfactory neurons more sensitive. Endocannabinoid modulation in the nose may therefore substantially influence food-seeking behavior.
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