期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 9, 页码 3380-3390出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4031-09.2010
关键词
-
资金
- Canadian Institute for Health Research (CIHR) [MT10250, OTG 88592]
- National Institutes of Health [R01 DK078056]
- Queen Elizabeth II
- Hotchkiss Brain Institute
- Alberta Heritage Foundation for Medical Research (AHFMR)
Output from the hypothalamic ventromedial nucleus (VMN) is anorexigenic and is supported by the excitatory actions of leptin. The VMN is also highly sensitive to the orexigenic actions of Neuropeptide Y (NPY). We report that NPY robustly inhibits VMN neurons by hyperpolarizing them and decreasing their ability to fire action potentials. This action was mediated by Y-1 receptors coupled to the activation of GIRKs (G-protein-coupled inwardly rectifying potassium channels). Approximately 80% of VMN neurons expressing leptin receptors were sensitive to the actions of NPY, whereas 75% of NPY-sensitive neurons in VMN also responded to glucose by being uniformly inhibited by elevations in glucose. Interestingly, only similar to 36% of NPY-sensitive, leptin receptor b-expressing neurons were also glucosensitive. We suggest that NPY inhibits VMN neurons that are excited by leptin, thereby arresting the anorexigenic tone exerted by VMN neurons. The results further suggest a dynamic interplay between anorexigenic and orexigenic neuromodulators within the VMN to directly affect energy balance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据