期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 40, 页码 13305-13313出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3010-10.2010
关键词
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资金
- Agencia Espanola de Cooperacion Internacional
- Direccion General de Investigacion Cientifica y Tecnica [BFU2008-01552]
- Instituto de Salud Carlos III [RD06/0010/0025]
- Consejeria de Salud (Fundacion Progreso y Salud)
- Fundacion Ramon Areces
- Junta de Andalucia [BIO-122]
Memory formation requires changes in gene expression, which are regulated by the activation of transcription factors and by changes in epigenetic factors. Poly[ADP]-ribosylation of nuclear proteins has been postulated as a chromatin modification involved in memory consolidation, although the mechanisms involved are not well characterized. Here we demonstrate that poly[ADP]-ribose polymerase 1 (PARP-1) activity and the poly[ADP]-ribosylation of proteins over a specific time course is required for the changes in synaptic plasticity related to memory stabilization in mice. At the molecular level, histone H1 poly[ADP]-ribosylation was evident in the hippocampus after the acquisition period, and it was selectively released in a PARP-1-dependent manner at the promoters of cAMP response element-binding protein and nuclear factor-kappa B dependent genes associated with learning and memory. These findings suggest that histone H1 poly[ADP]-ribosylation, and its loss at specific loci, is an epigenetic mechanism involved in the reprogramming of neuronal gene expression required for memory consolidation.
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