期刊
JOURNAL OF NEUROSCIENCE
卷 30, 期 40, 页码 13265-13271出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2190-10.2010
关键词
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资金
- ACI Neurosciences Integratives et Computationnelles [NIC 0083]
- Fondation Recherche Medicale [DLC20060206428]
- Agence Nationale de la Recherche (ANR) [07-JCJC-0108-01]
- French Ministry of Research
- Dutch Medical Research Council
- Dutch Scientific Council (NWO)
- European Union
- Prinses Beatrix Fonds
- Neuro-Bsik
- Lilly Foundation
Learning a new goal-directed behavioral task often requires the improvement of at least two processes, including an enhanced stimulus-response association and an optimization of the execution of the motor response. The cerebellum has recently been shown to play a role in acquiring goal-directed behavior, but it is unclear to what extent it contributes to a change in the stimulus-response association and/or the optimization of the execution of the motor response. We therefore designed the stimulus-dependent water Y-maze conditioning task, which allows discrimination between both processes, and we subsequently subjected Purkinje cell-specific mutant mice to this new task. The mouse mutants L7-PKCi, which suffer from impaired PKC-dependent processes such as parallel fiber to Purkinje cell long-term depression (PF-PC LTD), were able to acquire the stimulus-response association, but exhibited a reduced optimization of their motor performance. These data show that PF-PC LTD is not required for learning a stimulus-response association, but they do suggest that a PKC-dependent process in cerebellar Purkinje cells is required for optimization of motor responses.
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