期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 5, 页码 1496-1502出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5057-08.2009
关键词
synaptic plasticity; LTP; kinase; environmental; fear; memory formation
资金
- NCI NIH HHS [R01 CA047391-20, R01 CA047391, R01CA47391] Funding Source: Medline
- NINDS NIH HHS [P30 NS047243, P30-NS047243] Funding Source: Medline
The idea that qualities acquired from experience can be transmitted to future offspring has long been considered incompatible with current understanding of genetics. However, the recent documentation of non-Mendelian transgenerational inheritance makes such a Lamarckian-like phenomenon more plausible. Here, we demonstrate that exposure of 15-d-old mice to 2 weeks of an enriched environment (EE), that includes exposure to novel objects, elevated social interactions and voluntary exercise, enhances long-term potentiation (LTP) not only in these enriched mice but also in their future offspring through early adolescence, even if the offspring never experience EE. In both generations, LTP induction is augmented by a newly appearing cAMP/p38 MAP kinase-dependent signaling cascade. Strikingly, defective LTP and contextual fear conditioning memory normally associated with ras-grf knock-out mice are both masked in the offspring of enriched mutant parents. The transgenerational transmission of this effect occurs from the enriched mother to her offspring during embryogenesis. If a similar phenomenon occurs in humans, the effectiveness of one's memory during adolescence, particularly in those with defective cell signaling mechanisms that control memory, can be influenced by environmental stimulation experienced by one's mother during her youth.
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