期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 42, 页码 13158-13164出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2708-09.2009
关键词
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资金
- National Institute of Mental Health [70685]
- National Institute of Neurological Disease and Stroke [41328]
- Duke Institute for Brain Sciences
The dorsomedial prefrontal cortex (DMPFC) plays a central role in aspects of cognitive control and decision making. Here, we provide evidence for an anterior-to-posterior topography within the DMPFC using tasks that evoke three distinct forms of control demands-response, decision, and strategic-each of which could be mapped onto independent behavioral data. Specifically, we identify three spatially distinct regions within the DMPFC: a posterior region associated with control demands evoked by multiple incompatible responses, a middle region associated with control demands evoked by the relative desirability of decision options, and an anterior region that predicts control demands related to deviations from an individual's preferred decision-making strategy. These results provide new insight into the functional organization of DMPFC and suggest how recent controversies about its role in complex decision making and response mapping can be reconciled.
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