期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 16, 页码 5202-5206出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4432-08.2009
关键词
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资金
- Medical Research Council [G9900259]
- Wellcome Trust
- Oxford Biomedical Research Centre
- Burkitt Trust
- MRC [G9409531, G9900259, G0700399, G9901399, G0300665] Funding Source: UKRI
- Medical Research Council [G9900259, G0300665, G9901399, G0700399, G9409531] Funding Source: researchfish
Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.
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