期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 25, 页码 7966-7977出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1054-09.2009
关键词
-
资金
- Alexander von Humboldt Foundation
- European Union
- Bundesministerium fur Bildung und Forschung (BMBF)
- European Science Foundation [DFG 858/6-1]
- ENINET (Network of European Neuroscience Institutes) [LSHM-CT-2005-19063]
Survival and integration of new neurons in the hippocampal circuit are rate-limiting steps in adult hippocampal neurogenesis. Neuronal network activity is a major regulator of these processes, yet little is known about the respective downstream signaling pathways. Here, we investigate the role of cAMP response element-binding protein (CREB) signaling in adult hippocampal neurogenesis. CREB is activated in new granule neurons during a distinct developmental period. Loss of CREB function in a cell-autonomous manner impairs dendritic development, decreases the expression of the neurogenic transcription factor NeuroD and of the neuronal microtubule-associated protein, doublecortin (DCX), and compromises the survival of newborn neurons. In addition, GABA-mediated excitation regulates CREB activation at early developmental stages. Importantly, developmental defects after loss of GABA-mediated excitation can be compensated by enhanced CREB signaling. These results indicate that CREB signaling is a central pathway in adult hippocampal neurogenesis, regulating the development and survival of new hippocampal neurons downstream of GABA-mediated excitation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据