期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 40, 页码 12521-12531出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0640-09.2009
关键词
-
资金
- Yerkes National Primate Research Center through National Institutes of Health [RR00165]
- Ernst Strungmann Institute, Emory Alzheimer's Disease Research Center [AG025688]
- National Institute of General Medical Sciences
- National Institute of Mental Health [MH080007, MH082559]
Increasing evidence suggests that neuronal synchronization in the gamma band (30-100 Hz) may play an important role in mediating cognitive processes. Gamma-band synchronization provides for the optimal temporal relationship between two signals to produce the long-term synaptic changes that have been theorized to underlie memory formation. Although neuronal populations in the hippocampus oscillate in the gamma range, the role of these oscillations in memory formation is still unclear. To address this issue, we recorded neuronal activity in the hippocampus while macaque monkeys performed a visual recognition memory task. During the encoding phase of this task, hippocampal neurons displayed gamma-band synchronization. Additionally, enhanced gamma-band synchronization during encoding predicted greater subsequent recognition memory performance. These changes in synchronization reflect enhanced coordination among hippocampal neurons and may facilitate synaptic changes necessary for successful memory encoding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据