期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 50, 页码 15642-15649出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5096-09.2009
关键词
-
资金
- Swedish Medical Research Council [2004-5567, 2007-3630/4479, K2005-33X-15327]
- International Institute for Research on Paraplegia
- Swedish Brain Foundation
- foundations of Knut and Alice Wallenberg, Ake Wiberg, Magnus Bergwall, Ahlen, and Hedlund
- Uppsala University
- Knut and Alice Wallenberg Foundation
Neuronal circuits in the spinal cord that produce the rhythmic and coordinated activities necessary for limb movements are referred to as locomotor central pattern generators (CPGs). The identities and preceding development of neurons essential for coordination between left and right limbs are not yet known. We show that the ventral floor plate chemoattractant Netrin-1 preferentially guides dorsally originating subtypes of commissural interneurons, the majority of which are inhibitory. In contrast, the excitatory and ventralmost V3 subtype of interneurons have a normal number of commissural fibers in Netrin-1 mutant mice, thus being entirely independent of Netrin-1-mediated attraction. This selective loss of commissural fibers in Netrin-1 mutant mice resulted in an abnormal circuitry manifested by a complete switch from alternating to synchronous fictive locomotor activity suggesting that the most ventral-originating excitatory commissural interneurons are an important component of a left-right synchrony circuit in the locomotor CPG. Thus, during development, Netrin-1 plays a critical role for the establishment of a functional balanced CPG.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据