期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 3, 页码 630-637出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5204-08.2009
关键词
myelin-associated glycoprotein; MAG; myelin; Schwann cells; axon-glia interaction; axonal protection
资金
- National Multiple Sclerosis Society [R 3760-A-3]
- Nancy Davis Center Without Walls
- National Institutes of Health [K08 NS055135, R37 NS037096]
Progressive axonal degeneration follows demyelination in many neurological diseases, including multiple sclerosis and inherited demyelinating neuropathies, such as Charcot-Marie-Tooth disease. One glial molecule, the myelin-associated glycoprotein (MAG), located in the adaxonal plasmalemma of myelin-producing cells, is known to signal to the axon and to modulate axonal caliber through phosphorylation of axonal neurofilament proteins. This report establishes for the first time that MAG also promotes resistance to axonal injury and prevents axonal degeneration both in cell culture and in vivo. This effect on axonal stability depends on the RGD domain around arginine 118 in the extracellular portion of MAG, but it is independent of Nogo signaling in the axon. Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss.
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