期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 32, 页码 9961-9966出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0795-09.2009
关键词
-
资金
- National Institute of Mental Health [MH84051, MH46729]
- HealthEmotions Research Institute
- Meriter Hospital
The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmissionandis implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [C-11]DASB [C-11]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament was previously established. 5-HTT availability in the amygdalohippocampal area and bed nucleus of the stria terminalis correlated positively with individual differences in a behavioral and neuroendocrine composite of anxious temperament. 5-HTT availability also correlated positively with stress-induced metabolic activity within these regions. Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据