期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 31, 页码 9700-9703出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5928-08.2009
关键词
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资金
- Ministry of Science and Technology, the Republic of Korea [M103KV010025-07K2201-02510]
- National Research Foundation of Korea [22-2009-00-033-00, 인06A1602] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Use-dependent synaptic modifications in the lateral nucleus of the amygdala (LA) have been suggested to be the cellular analog of memory trace after pavlovian fear conditioning. However, whether neurophysiological changes in the LA are produced as a direct consequence of associative learning awaits additional proof. Using microstimulation of the medial geniculate nucleus of the thalamus as the conditioned stimulus (CS), we demonstrated that contingent pairings of the brain-stimulation CS and a footshock unconditioned stimulus lead to enhanced synaptic efficacy in the thalamic input to the LA, supporting the hypothesis that localized synaptic alterations underlie fear memory formation.
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