期刊
JOURNAL OF NEUROSCIENCE
卷 29, 期 25, 页码 7948-7956出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0229-09.2009
关键词
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资金
- Belgian Fonds de la Recherche Scientifique (FNRS)
- Fondation Medicale Reine Elisabeth, the University of Liege
- Poles d'Attraction Interuniversitaire/Interuniversity Attraction Poles [P6/29]
- Wellcome Trust [GR069714MA]
- Biotechnology and Biological Sciences Research Council [BB/F022883/1]
- Fonds de recherche sur la nature et les technologies (Quebec)
- BBSRC [BB/F022883/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F022883/1] Funding Source: researchfish
Cognition is regulated across the 24 h sleep-wake cycle by circadian rhythmicity and sleep homeostasis through unknown brain mechanisms. We investigated these mechanisms in a functional magnetic resonance imaging study of executive function using a working memory 3-back task during a normal sleep-wake cycle and during sleep loss. The study population was stratified according to homozygosity for a variable-number (4 or 5) tandem-repeat polymorphism in the coding region of the clock gene PERIOD3. This polymorphism confers vulnerability to sleep loss and circadian misalignment through its effects on sleep homeostasis. In the less-vulnerable genotype, no changes were observed in brain responses during the normal-sleep wake cycle. During sleep loss, these individuals recruited supplemental anterior frontal, temporal and subcortical regions, while executive function was maintained. In contrast, in the vulnerable genotype, activation in a posterior prefrontal area was already reduced when comparing the evening to the morning during a normal sleep-wake cycle. Furthermore, in the morning after a night of sleep loss, widespread reductions in activation in prefrontal, temporal, parietal and occipital areas were observed in this genotype. These differences occurred in the absence of genotype-dependent differences in circadian phase. The data show that dynamic changes in brain responses to an executive task evolve across the sleep-wake and circadian cycles in a regionally specific manner that is determined by a polymorphism which affects sleep homeostasis. The findings support a model of individual differences in executive control, in which the allocation of prefrontal resources is constrained by sleep pressure and circadian phase.
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