期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 25, 页码 6453-6458出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0573-08.2008
关键词
synchrony; functional connectivity; corpus callosotomy; epilepsy; fMRI; resting state
资金
- NINDS NIH HHS [P50 NS006833, NS06833, P50 NS006833-410032] Funding Source: Medline
Slow (< 0.1 Hz), spontaneous fluctuations in the functional magnetic resonance imaging blood oxygen level-dependent ( BOLD) signal have been shown to exhibit phase coherence within functionally related areas of the brain. Surprisingly, this phenomenon appears to transcend levels of consciousness. The genesis of coherent BOLD fluctuations remains to be fully explained. We present a resting state functional connectivity study of a 6-year-old child with a radiologically normal brain imaged both before and after complete section of the corpus callosum for the treatment of intractable epilepsy. Postoperatively, there was a striking loss of interhemispheric BOLD correlations with preserved intrahemispheric correlations. These unique data provide important insights into the relationship between connectional anatomy and functional organization of the human brain. Such observations have the potential to increase our understanding of large-scale brain systems in health and disease as well as improve the treatment of neurologic disorders.
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