期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 46, 页码 11746-11752出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3860-08.2008
关键词
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资金
- NIDA NIH HHS [R01 DA020796-03, R01 DA020796] Funding Source: Medline
- NINDS NIH HHS [P01 NS037409, P01 NS037409-08, P30 NS045776, R01 NS043426, P30 NS045776-05, R01 NS043426-05] Funding Source: Medline
The ability of neurons to migrate to their appropriate positions in the developing brain is critical to brain architecture and function. Recent research has elucidated different modes of neuronal migration and the involvement of a host of signaling factors in orchestrating the migration, as well as vulnerabilities of this process to environmental and genetic factors. Here we discuss the role of cytoskeleton, motor proteins, and mechanisms of nuclear translocation in radial and tangential migration of neurons. We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans.
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