期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 17, 页码 4331-4335出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0716-08.2008
关键词
pruritus; cowhage; Mucuna pruriens; cysteine protease; protease-activated receptor; receptor
资金
- NCRR NIH HHS [UL1 RR024139, UL1 RR024139-03, UL1 RR0249139] Funding Source: Medline
- NINDS NIH HHS [K25 NS047300, P01 NS 047300, P01 NS047399-04, P01 NS047399] Funding Source: Medline
Cowhage spicules provide an important model for histamine-independent itch. We determined that the active component of cowhage, termed mucunain, is a novel cysteine protease. We isolated mucunain and demonstrate that both native and recombinant mucunain evoke the same quality of itch in humans. We also show that mucunain is a ligand for protease-activated receptors two and four. These results support and expand the relationship between proteases, protease-activated receptors, and itch.
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