期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 24, 页码 6104-6110出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0437-08.2008
关键词
ripple; sharp wave; oscillation; interneuron; human hippocampus; EEG
资金
- NCRR NIH HHS [P41 RR013642-107070, P41 RR013642-070045, P41 RR013642-097216, P41 RR013642, P41 RR013642-080045] Funding Source: Medline
- NINDS NIH HHS [R37 NS033310-14, NS-02808, P01 NS002808-460051, P01 NS002808-46, P01 NS002808-469001, R37 NS033310-15, P01 NS002808-470050, R01 NS033310, P01 NS002808-460050, P01 NS002808-450051, RF1 NS033310, P01 NS002808-450050, P01 NS002808-47, R37 NS033310, NS-33310, P01 NS002808, P01 NS002808-470051] Funding Source: Medline
High-frequency field ripples occur in the rodent hippocampal formation and are assumed to depend on interneuron type-specific firing patterns, structuring the activity of pyramidal cells. Ripples with similar characteristics are also present in humans, yet their underlying cellular correlates are still unknown. By in vivo recording interneurons and pyramidal cells in the human hippocampal formation, we find that cell type-specific firing patterns and phase-locking on a millisecond timescale can be distinguished during ripples. In particular, pyramidal cells fired preferentially at the highest amplitude of the ripple, but interneurons began to discharge earlier than pyramidal cells. Furthermore, a large fraction of cells were phase-locked to the ripple cycle, but the preferred phase of discharge of interneurons followed the maximum discharge probability of pyramidal neurons. These relationships between human ripples and unit activity are qualitatively similar to that observed in vivo in the rodents, suggesting that their underlying mechanisms are similar.
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