期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 20, 页码 5178-5188出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1076-08.2008
关键词
barrel; cortex; development; network; neuron; plasticity
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NINDS NIH HHS [R01 NS038259-01] Funding Source: Medline
Silencing of the Fmr1 gene causes fragile X syndrome. Although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments in Fmr1 knock-out (ko) mice, the specific cortical circuits affected in the syndrome are unknown. Here, we investigated the development of excitatory projections in the barrel cortex of Fmr1 ko mice. In 2-week-old Fmr1 ko mice, a major ascending projection connecting layer 4 (L4) to L3 (L43L3), was defective in multiple and independent ways: its strength was reduced, caused by a lower connection probability; the axonal arbors of L4 cells were spatially diffuse in L2/3; the L43L3 projection did not show experience-dependent plasticity. By 3 weeks, the strength of the L43L3 projection was similar to that of wild type. Our data indicate that Fmr1 shapes sensory cortical circuits during a developmental critical period.
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