期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 46, 页码 11753-11759出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3797-08.2008
关键词
epigenetics; chromatin; DNA methylation; histone; transcription; gene
资金
- NCRR NIH HHS [S10 RR024747, S10 RR024747-01] Funding Source: Medline
- NICHD NIH HHS [R01 HD041462, R01 HD041462-06A2, R01 HD048799, R01 HD048799-03] Funding Source: Medline
- NIDA NIH HHS [R37 DA007359-15, T32 DA007290-14, R37 DA007359, T32 DA007290] Funding Source: Medline
- NIMH NIH HHS [R01 MH074114-01, K99 MH082106-01, R01 MH081004, R01 MH074114, R01 MH086509, K99 MH082106, R01 MH081004-01A1] Funding Source: Medline
It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.
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