期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 10, 页码 2563-2575出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5407-07.2008
关键词
nicotine; addiction; synaptic plasticity; synaptic vesicle release; acetylcholine receptor; synaptic communication; multivesicular; mEPSCs
资金
- NIDA NIH HHS [R21 DA019453-01, R01 DA010266-07, R21 DA019453, 5 R21 DA019453, R01 DA010266-08, R01 DA010266-06, R01 DA010266, R01 DA 10266] Funding Source: Medline
Presynaptic action potential-independent transmitter release is a potential means of information transfer across synapses. Weshow that in the hippocampal mossy fiber boutons, activation of the alpha 7-subtype of nicotinic acetylcholine receptors (alpha 7-nAChRs) results in a large increase in the amplitude of spontaneous events, resulting from concerted release of multiple quanta from the mossy fiber boutons. This amplitude increase is abolished at low temperatures. Activation of alpha 7-nAChRs causes a rise in intraterminal calcium at mossy fiber boutons, involving ryanodine receptors. Regulation of concerted release requires the subsequent activation of presynaptic calcium/calmodulin-dependent protein kinase II (CaMKII). Activation of CaMKII is required to drive presynaptic action potential-independent transmission at the mossy fiber-CA3 pyramidal cell synapse. The effects of alpha 7-nAChR activation are mediated by biologically relevant doses of nicotine. Our results demonstrate a novel form of synaptic plasticity mediated by presynaptic alpha 7-nAChRs and store calcium that is temporally different and might respond to a different history of synaptic activity than that mediated by incoming action potentials.
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