期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 14, 页码 3804-3813出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0224-08.2008
关键词
subventricular zone; neural stem cells; neural progenitor cells; ependymal cells; repair; aging
资金
- NINDS NIH HHS [NS050338, NS45894, R01 NS050338-02, R01 NS050338] Funding Source: Medline
The subventricular zone ( SVZ) of the adult mouse brain is a narrow stem cell niche that lies along the length of the lateral wall of the lateral ventricles. The SVZ supports neurogenesis throughout adulthood; however, with increasing age, the ventral SVZ deteriorates and only the dorsolateral SVZ remains neurogenic. Associated with the elderly dorsolateral SVZ, we reported previously an increased number of astrocytes interposed within the adjacent ependymal lining. Here, we show that astrocytes integrated within the ependyma are dividing, BrdU-labeled astrocytes that share cellular adherens with neighboring ependymal cells. By tracking BrdU-labeled astrocytes over time, we observed that, as they incorporated within the ependyma, they took on antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supported regenerative repair in the aging brain. A similar form of SVZ-mediated ependyma repair was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminidase. Together, this work identifies a novel non-neuronal mechanism of regenerative repair by the adult SVZ.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据