期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 42, 页码 10687-10695出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2933-08.2008
关键词
levodopa; Parkinson's disease; sequence learning; deactivation; default mode network; COMT genotype
资金
- National Institutes of Health-National Institute of Neurological Disorders and Stroke [R01 35069]
- General Clinical Research Center of The Feinstein Institute for Medical Research [M01 RR018535]
Cognitive processing is associated with deactivation of the default mode network. The presence of dopaminoceptive neurons in proximity to the medial prefrontal node of this network suggests that this neurotransmitter may modulate deactivation in this region. We therefore used positron emission tomography to measure cerebral blood flow in 15 Parkinson's disease (PD) patients while they performed a motor sequence learning task and a simple movement task. Scanning was conducted before and during intravenous levodopa infusion; the pace and extent of movement was controlled across tasks and treatment conditions. In normal and unmedicated PD patients, learning-related deactivation was present in the ventromedial prefrontal cortex (p < 0.001). This response was absent in the treated condition. Treatment-mediated changes in deactivation correlated with baseline performance (p < 0.002) and with the val(158)met catechol-O-methyltransferase genotype. Our findings suggest that dopamine can influence prefrontal deactivation during learning, and that these changes are linked to baseline performance and genotype.
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