期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 50, 页码 13505-13510出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2127-08.2008
关键词
adhesion; knock-out mice; working memory; learning; memory; synaptic transmission; cognition; attention; selective attention; CHL1
资金
- National Institute on Aging [R01 AG029289, AG022698]
- Busch Foundation
In addition to its role in axon growth and neuronal migration, the close homolog of L1 (CHL1), a member of the L1 family of cell adhesion molecules, is involved in synaptic plasticity. To date, little has been done to disassociate the role of CHL1 during adulthood from its role during development. To address this issue, mice conditionally deficient in CHL1 (lacking CHL1 only after the third postnatal week) were tested relative to littermate controls as adults in five learning tasks and several tests of working memory (including duration and selective attention). CHL1-deficient mice showed no impairments in the learning tasks compared with wild-type controls. CHL1 deletion had no effect on selective attention despite its widespread impairment of working memory duration. These results suggest a role for CHL1 in the adult-brain in the short-term maintenance of information.
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